Anti-Human CD209 (DC-SIGN) FITC

Description: The eB-h209 monoclonal antibody reacts with human CD209, also known as DC-SIGN, a 44 kDa type II transmembrane protein. DC-SIGN contains a C-type lectin binding domain and binds ICAM-3, ICAM-2, and HIV virus. Human dendritic cells preferentially express DC-SIGN. It has been postulated that DC-SIGN serves as a receptor for capture, trafficking, and transmission of HIV to T cells and supports primary immune response. eB-h209 was developed against a C-terminal peptide of human DC-SIGN.

References: Pohlmann, S, F Baribaud, et al. (2001). DC-SIGN Interactions with Human Immunodeficiency Virus type 1 and 2 and Simian Immunodeficiency Virus. J Virol. 75(10):4664-4672

Geijtenbeek, T.B, D.S. Douglas, et al. (2000) DC-SIGN, a Dendritic Cell-Specific HIV-1-Binding protein that Enhances trans-Infection of T cells. Cell 100(5): 587-597.

Geijtenbeek, T.B, R Torensma, et al. (2000). Identification of DC-SIGN, a Novel Dendritic Cell-Specific ICAM-3 Receptor that Supports Primary Immune Responses. Cell 100(5): 575-585.

Geijtenbeek, T.B, D.J. Krooshop, et al. (2000). DC-SIGN-ICAM-2 Interaction Mediates Dendritic Cell Trafficking. Nat. Immunol. 1(4):353-357.