Anti-Human CD197 (CCR7) Purified

Description: The CCR7.6B3 monoclonal antibody reacts with human CCR7, also known as EBI-1 and CD197. CCR7 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains and functions as a receptor for 6Ckine/SLC (secondary lymphoid-tissue chemokine) and MIP-3β/ELC (EBI1-ligand chemokine). CCR7 is expressed predominantly on naive T cells characterized as CD45RA⁺CCR7⁺ in both CD4 and CD8 populations in peripheral blood as well as on dendritic cells.

References:
Hasegawa, H., T. Nomura, et al. 2000. Increased chemokine receptor CCR7/EBI1 expression enhances the infiltration of lymphoid organs by adult T-cell leukemia cells. Blood 95(1): 30-8.

Hirose J, Kawashima H, et al. 2002. Chondroitin sulfate B exerts its inhibitory effect on secondary lymphoid tissue chemokine (SLC) by binding to the C-terminus of SLC. Biochim Biophys Acta. 1571(3):219-24. (FC, PubMed)

Hasegawa H, Nomura T, et al. 2000. Increased chemokine receptor CCR7/EBI1 expression enhances the infiltration of lymphoid organs by adult T-cell leukemia cells. Blood 95(1):30-8. (FC, PubMed)