Anti-Human CD196 (CCR6) Purified

Description: This R6H1 monoclonal antibody reacts with CD196 (also known as CCR6), a seven transmembrane G protein-coupled receptor expressed on T, B, dendritic, natural killer, and Langerhans cells. This CC chemokine receptor uniquely binds MIP-3a/CCL20, a chemoattractant for dendritic cells, effector/memory T cells, and B cells. CD196 is also involved in host defense and inflammation at epithelial sites. Furthermore, this receptor has been implicated in Th17 differentiation and CD4+FoxP3+ regulatory T cell development.

References: Liu H, Rohowsky-Kochan C.Regulation of IL-17 in human CCR6+ effector memory T cells. J Immunol. 2008 Jun 15;180(12):7948-57

Singh SP, Zhang HH, Foley JF, Hedrick MN, Farber JM.Human T cells that are able to produce IL-17 express the chemokine receptor CCR6. J Immunol. 2008 Jan 1;180(1):214-21

Lim HW, Lee J, Hillsamer P, Kim CH.Human Th17 cells share major trafficking receptors with both polarized effector T cells and FOXP3+ regulatory T cells. J Immunol. 2008 Jan 1;180(1):122-9

Shutyser E, Struyf S, Van Damme J.The CC chemokine CCL20 and its receptor CCR6. Cytokine Growth Factor Rev. 2003 Oct;14(5):409-26.

Carramolino L, Kremer L, Goya I, Varona R, Buesa JM, Gutiérrez J, Zaballos A, Martínez-A C, Márquez G. Down-regulation of the beta-chemokine receptor CCR6 in dendritic cells mediated by TNF-alpha and IL-4. J Leukoc Biol. 1999 Nov;66(5):837-44. (clone R6H1, FC, Pubmed)