Anti-Human CD196 (CCR6) PE-Cy7

Clone: R6H1

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 25-1969

Cat. No.	Size
25-1969-41	25 tests
25-1969-42	100 tests
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Staining of normal human peripheral blood cells with Anti-Human CD19 APC (cat. 17-0199) and Mouse...View More

Description

Description: This R6H1 monoclonal antibody reacts with CD196 (also known as CCR6), a seven transmembrane G protein-coupled receptor expressed on T, B, dendritic, natural killer, and Langerhans cells. This CC chemokine receptor uniquely binds MIP-3a/CCL20, a chemoattractant for dendritic cells, effector/memory T cells, and B cells. CD196 is also involved in host defense and inflammation at epithelial sites. Furthermore, this receptor has been implicated in Th17 differentiation and CD4+FoxP3+ regulatory T cell development.

Details

Host	Mouse
Isotype	IgG1
Reactivity	Human
Conjugate	PE-Cyanine7
Laser	Blue Laser, Green Laser, Yellow-Green Laser
Emit	775 nm
Excite	488 - 561 nm
Legal	FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT # 5,268,486, 5,569,587 AND 5,627,027 AND FOREIGN EQUIVALENTS AND PENDING APPLICATIONS. THIS MATERIAL IS SUBJECT TO PROPRIETARY RIGHTS OF GE HEALTHCARE BIO-SCIENCES CORP. AND CARNEGIE MELLON UNIVERSITY AND MADE AND SOLD UNDER LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. THIS PRODUCT IS LICENSED FOR SALE ONLY FOR RESEARCH. IT IS NOT LICENSED FOR ANY OTHER USE. THERE IS NO IMPLIED LICENSE HEREUNDER FOR ANY COMMERCIAL USE. COMMERCIAL USE shall include: 1. sale, lease, license or other transfer of the material or any material derived or produced from it; 2. sale, lease, license or other grant of rights to use this Material or any material derived or produced from it; 3. use of this material to perform services for a fee for third parties. IF YOU REQUIRE A COMMERCIAL LICENSE TO USE THIS MATERIAL AND DO NOT HAVE ONE, RETURN THIS MATERIAL, UNOPENED TO EBIOSCIENCE, INC. 10255 SCIENCE CENTER DRIVE, SAN DIEGO, CALIFORNIA 92121 USA AND ANY MONEY PAID FOR THE MATERIAL WILL BE REFUNDED.
Reported Applications	Flow Cytometric Analysis

Documentation

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
14-1969	Anti-Human CD196 (CCR6) Purified			FC, IP, WB	RUO
17-1969	Anti-Human CD196 (CCR6) APC	633 - 647 nm	660 nm	FC	RUO
46-1969	Anti-Human CD196 (CCR6) PerCP-eFluor® 710	488 nm	710 nm	FC	RUO
12-1969	Anti-Human CD196 (CCR6) PE	488 - 561 nm		FC	RUO
11-1969	Anti-Human CD196 (CCR6) FITC	488 nm		FC	RUO

Related Products

Cat. No.	Name	Excite	Emit	Application	Reg.
17-0199	Anti-Human CD19 APC	633 - 647 nm	660 nm	FC	RUO
25-4714	Mouse IgG1 K Isotype Control PE-Cyanine7	488 - 561 nm	775 nm	FC	RUO

References

References: Liu H, Rohowsky-Kochan C.Regulation of IL-17 in human CCR6+ effector memory T cells. J Immunol. 2008 Jun 15;180(12):7948-57

Singh SP, Zhang HH, Foley JF, Hedrick MN, Farber JM.Human T cells that are able to produce IL-17 express the chemokine receptor CCR6. J Immunol. 2008 Jan 1;180(1):214-21

Lim HW, Lee J, Hillsamer P, Kim CH.Human Th17 cells share major trafficking receptors with both polarized effector T cells and FOXP3+ regulatory T cells. J Immunol. 2008 Jan 1;180(1):122-9

Shutyser E, Struyf S, Van Damme J.The CC chemokine CCL20 and its receptor CCR6. Cytokine Growth Factor Rev. 2003 Oct;14(5):409-26.

Carramolino L, Kremer L, Goya I, Varona R, Buesa JM, Gutiérrez J, Zaballos A, Martínez-A C, Márquez G. Down-regulation of the beta-chemokine receptor CCR6 in dendritic cells mediated by TNF-alpha and IL-4. J Leukoc Biol. 1999 Nov;66(5):837-44. (clone R6H1, FC, Pubmed)

View More Products

Antigens	Area of Biology	Cell Type	Formats
CD196 (CCR6)	Cell Signaling Cytokines, Chemokines, Growth Factors Angiogenesis	B Cells Dendritic Cells T Cells Th17 Cells	PE-Cyanine7