Anti-Human CD193 (CCR3) PE

Also known as: C-C chemokine receptor type 3, CMKBR3

Clone: eBio5E8-G9-B4 (5E8-G9-B4)

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 12-1939

Cat. No. Size
12-1939-41 25 tests
12-1939-42 100 tests

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Data for Anti-Human CD193 (CCR3) PE.

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  • Data for Anti-Human CD193 (CCR3) PE.
Description

Description: The eBio5E8-G9-B4 monoclonal antibody reacts with human CD193 (CCR3, CKR3). CD193 is a member of the seven transmembrane G-protein coupled receptor (GPCR) family, and is a high affinity chemokine receptor for the chemokines eotaxin-1 (CCL11), eotaxin-2 (CCL24), eotaxin-3 (CCL26) and MCP-4 (CCL13), but has also been reported to bind RANTES, MCP-3 and MCP-4. CD193 is highly expressed on the surface of eosinophils, and is the key eosinophil chemokine receptor responsible for the regulation of eosinophil migration and function. In addition to eosinophils, CD193 is also expressed on CD4+ TH2 cells, basophils, mast cells, mononuclear phagocytes, platelets, CD34+ hematopoietic progenitors and airway epithelial cells. CD193 likely plays an important role in the migration of eosinophils in allergic airway inflammation and asthma. CD193 can also serve as a receptor for HIV-1 cell entry.

Details
Host Mouse
Isotype IgG2b, kappa
Reactivity Human
Conjugate PE
Laser Blue Laser
Emit 575 nm
Excite 488 nm
Reported Applications Flow Cytometric Analysis
Documentation

For complete product information, please download the TDS or IFU document.

TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
14-1939 Anti-Human CD193 (CCR3) Purified FC RUO
17-1939 Anti-Human CD193 (CCR3) APC 633 nm 660 nm FC RUO
References

References: Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, LaRosa G, Newman W, Gerard N, Gerard C, Sodroski J. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.Cell. 1996 Jun 28;85(7):1135-48.

Heath H, Qin S, Rao P, Wu L, LaRosa G, Kassam N, Ponath PD, Mackay CR. Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody.J Clin Invest. 1997 Jan 15;99(2):178-84.

Forssmann U, Uguccioni M, Loetscher P, Dahinden CA, Langen H, Thelen M, Baggiolini M. Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes.J Exp Med. 1997 Jun 16;185(12):2171-6.

Sallusto F, Mackay CR, Lanzavecchia A. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells.Science. 1997 Sep 26;277(5334):2005-7.