CD19 APC

Description: The SJ25C1 monoclonal antibody reacts with human CD19, a 95 kDa transmembrane glycoprotein. CD19 is expressed by B cells during all stages of development excluding the terminally differentiated plasma cells. Follicular dendritic cells also express this molecule. CD19, along with CD21, CD81, Leu13, and MHC class II, form a multimolecular complex that associates with the BCR. Signaling through CD19 induces tyrosine phosphorylation, calcium flux and proliferation of B cells.

References: Knapp W, Dorken B, et al, eds. Leucocyte Typing IV: White Cell Differentiation Antigens. Oxford University Press. New York. 1989.

Schlossman S, Bloumsell L, et al, eds. Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York. 1995.

Moldenhauer G, Dörken B, Schwartz R, Pezzutto A, Knops J, Hammerling GJ. Analysis of ten Blymphocyte-specific workshop monoclonal antibodies. In: Reinherz EL, Haynes BF, Nadler LM,Bernstein ID, eds. Leukocyte Typing II: Human B Lymphocytes. Vol 2. New York, NY: Springer-Verlag;1986:61-67.