Anti-Human CD184 (CXCR4) PE-Cyanine5

Also known as: Fusin

Clone: 12G5

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 15-9999

Cat. No.	Size
15-9999-41	25 tests
15-9999-42	100 tests
Please inquire about custom configurations or bulk packaging.

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Staining of normal human peripheral blood cells with staining buffer (autofluorescence) (open...View More

Description

Description: The 12G5 monoclonal antibody reacts with human CXCR4 (CD184), also termed Fusin, LESTR, or HUMSTR. Fusin is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a coreceptor for X4 HIV-1 entry into CD4⁺ cells. CXCR4 is expressed predominantly on naive T cell subsets of peripheral blood and is rapidly upregulated by PHA and IL-2 stimulation. 12G5 shows partial inhibition of chemotaxis and calcium influx induced by SDF-1 (the natural ligand of CXCR4), blocks CD4-independent HIV-2 infection, and blocks CD4-dependent infection by some T-tropic HIV-1 isolates.

Details

Host	Mouse
Isotype	IgG2a, kappa
Reactivity	Human
Conjugate	PE-Cyanine5
Laser	Blue Laser, Green Laser, Yellow-Green Laser
Excite	488 - 561 nm
Legal	FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT # 5,268,486, 5,569,587 AND 5,627,027 AND FOREIGN EQUIVALENTS AND PENDING APPLICATIONS. THIS MATERIAL IS SUBJECT TO PROPRIETARY RIGHTS OF GE HEALTHCARE BIO-SCIENCES CORP. AND CARNEGIE MELLON UNIVERSITY AND MADE AND SOLD UNDER LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. THIS PRODUCT IS LICENSED FOR SALE ONLY FOR RESEARCH. IT IS NOT LICENSED FOR ANY OTHER USE. THERE IS NO IMPLIED LICENSE HEREUNDER FOR ANY COMMERCIAL USE. COMMERCIAL USE shall include: 1. sale, lease, license or other transfer of the material or any material derived or produced from it; 2. sale, lease, license or other grant of rights to use this Material or any material derived or produced from it; 3. use of this material to perform services for a fee for third parties. IF YOU REQUIRE A COMMERCIAL LICENSE TO USE THIS MATERIAL AND DO NOT HAVE ONE, RETURN THIS MATERIAL, UNOPENED TO EBIOSCIENCE, INC. 10255 SCIENCE CENTER DRIVE, SAN DIEGO, CALIFORNIA 92121 USA AND ANY MONEY PAID FOR THE MATERIAL WILL BE REFUNDED.
Reported Applications	Flow Cytometric Analysis

Documentation

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
14-9999	Anti-Human CD184 (CXCR4) Purified			FC, FA	RUO
25-9999	Anti-Human CD184 (CXCR4) PE-Cy7	488 - 561 nm	775 nm	FC	RUO
12-9999	Anti-Human CD184 (CXCR4) PE	488 - 561 nm	575 nm	FC	RUO
17-9999	Anti-Human CD184 (CXCR4) APC	633 - 647 nm	660 nm	FC	RUO
13-9999	Anti-Human CD184 (CXCR4) Biotin			FC	RUO
16-9999	Anti-Human CD184 (CXCR4) Functional Grade Purified			FC, FA	RUO

Related Products

Cat. No.	Name	Excite	Emit	Application	Reg.
15-4724	Mouse IgG2a K Isotype Control PE-Cyanine5	488 - 561 nm		FC	RUO

References

References: McKnight, A. et al. (1997). Inhibition of human immunodeficiency virus fusion by a monoclonal antibody to a coreceptor (CXCR4) is both cell type and virus strain dependent. J Virol 71(2): 1692-6.

Bleul, C. et al. (1997). The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc Natl Acad Sci U S A 94(5): 1925-30.

View More Products

Antigens	Area of Biology	Cell Type	Formats
CD184 (CXCR4)	Stem Cell Biology Cell Signaling Cytokines, Chemokines, Growth Factors Angiogenesis	Mesenchymal Stem Cells T Cells	PE-Cyanine5