Anti-Human CD184 (CXCR4) Functional Grade Purified

Also known as: C-X-C chemokine receptor type 4, Fusin, SDF-1 receptor

Clone: 12G5

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 16-9999

Cat. No. Size
16-9999-81 50 ug
16-9999-85 500 ug

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Data for Anti-Human CD184 (CXCR4) Functional Grade Purified.

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  • Data for Anti-Human CD184 (CXCR4) Functional Grade Purified.
Description

Description: The 12G5 monoclonal antibody reacts with human CXCR4 (CD184), also termed Fusin, LESTR, or HUMSTR. Fusin is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a coreceptor for X4 HIV-1 entry into CD4+ cells. CXCR4 is expressed predominantly on naive T cell subsets of peripheral blood and is rapidly upregulated by PHA and IL-2 stimulation. 12G5 shows partial inhibition of chemotaxis and calcium influx induced by SDF-1 (the natural ligand of CXCR4), blocks CD4-independent HIV-2 infection, and blocks CD4-dependent infection by some T-tropic HIV-1 isolates.

Details
Host Mouse
Isotype IgG2a, kappa
Reactivity Human
Conjugate Functional Grade Purified
Reported Applications Flow Cytometric Analysis, Functional Assays
Documentation

For complete product information, please download the TDS or IFU document.

TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
17-9999 Anti-Human CD184 (CXCR4) APC 633 nm 660 nm FC RUO
15-9999 Anti-Human CD184 (CXCR4) PE-Cy5 488 nm 670 nm FC RUO
14-9999 Anti-Human CD184 (CXCR4) Purified FC, FA RUO
12-9999 Anti-Human CD184 (CXCR4) PE 488 nm 575 nm FC RUO
13-9999 Anti-Human CD184 (CXCR4) Biotin FC RUO
25-9999 Anti-Human CD184 (CXCR4) PE-Cy7 488 nm 760 nm FC RUO
References

References:
McKnight, A. et al. (1997). "Inhibition of human immunodeficiency virus fusion by a monoclonal antibody to a coreceptor (CXCR4) is both cell type and virus strain dependent." J Virol 71(2): 1692-6.
Bleul, C. et al. (1997). "The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes." Proc Natl Acad Sci U S A 94(5): 1925-30.