Anti-Human CD160 Alexa Fluor® 488

Also known as: BY55

Clone: BY55

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 53-1609

Cat. No.	Size
53-1609-41	25 tests
53-1609-42	100 tests
Please inquire about custom configurations or bulk packaging.

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Staining of normal human peripheral blood cells with Anti-Human CD3 PE (cat. 12-0037) and Anti-Human...View More

Description

Description: This BY55 monoclonal antibody reacts with human CD160, a member of the immunoglobulin superfamily expressed on natural killer cells, natural killer T cells, activated and/or memory CD4 and CD8 T cells, gamma/delta T cells, and intraepithelial cells. CD160 has been reported to bind herpes virus entry mediator (HVEM) in a complex with LIGHT and BTLA to deliver an inhibitory signal to CD4 T cells that abrogates proliferation and cytokine production. Three alternative splice variants of CD160 have also been identified in natural killer cells.

Details

Host	Mouse
Isotype	IgM
Reactivity	Human
Conjugate	Alexa Fluor 488
Laser	Blue Laser
Emit	519 nm
Excite	488 nm
Legal	Alexa Fluor® and Pacific Blue® are registered trademarks of and licensed under patents assigned to Molecular Probes, Inc. for research use only. This product is subject to an agreement between Molecular Probes, Inc. and eBioscience, and the manufacture, use, sale or import of this product may be subject to one or more U.S. patents, pending applications and corresponding foreign equivalents, owned by Molecular Probes, Inc. (a wholly owned subsidiary of Invitrogen Corp). The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product for life science research or as an ASR. The buyer cannot use this product for manufacturing or for any other screening (specifically including use in combination with microarrays or High Content Screening) or testing purpose, other than as an ASR. For information on purchasing a license to this product for purposes other than life science research or use as an ASR, contact Molecular Probes, Inc.
Reported Applications	Flow Cytometric Analysis

Documentation

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
50-1609	Anti-Human CD160 eFluor® 660 (Alexa Fluor® 647 replacement)	633 - 647 nm	668 nm	FC	RUO
12-1609	Anti-Human CD160 PE	488 - 561 nm		FC	RUO

Related Products

Cat. No.	Name	Excite	Emit	Application	Reg.
12-0037	Anti-Human CD3 PE	488 - 561 nm	575 nm	FC	RUO
12-0567	Anti-Human CD56 (NCAM) PE	488 - 561 nm		FC	RUO

References

References: Cai G, Freeman GJ. The CD160, BTLA, LIGHT/HVEM pathway: a bidirectional switch regulating T-cell activation. Immunol Rev. 2009 May;229(1):244-58.

Giustiniani J, Bensussan A, Marie-Cardine A. Identification and characterization of a transmembrane isoform of CD160 (CD160-TM), a unique activating receptor selectively expressed upon human NK cell activation. J Immunol. 2009 Jan 1;182(1):63-71.

Cai G, Anumanthan A, Brown JA, Greenfield EA, Zhu B, Freeman GJ.CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator. Nat Immunol. 2008 Feb;9(2):176-85.

Bensussan A, Gluckman E, el Marsafy S, Schiavon V, Mansur IG, Dausset J, Boumsell L, Carosella E. BY55 monoclonal antibody delineates within human cord blood and bone marrow lymphocytes distinct cell subsets mediating cytotoxic activity. Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):9136-40. (BY55, FC,Pubmed)

View More Products

Antigens	Area of Biology	Cell Type	Formats
CD160	Innate Immunity Angiogenesis	B Cells NK & NKT Cells T Cells	Alexa Fluor 488