Anti-Human CD158a PE-Cyanine7

Also known as: KIR2DL1/S1, KIR

Clone: HP-MA4

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 25-1589

Cat. No.	Size
25-1589-41	25 tests
25-1589-42	100 tests
Please inquire about custom configurations or bulk packaging.

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Staining of normal human peripheral blood cells with Anti-Human CD56 (NCAM) APC (cat. 17-0567) and...View More

Description

Description: The monoclonal antibody HP-MA4 recognizes the 58 kDa protein CD158a also known as KIR2DL1/S1. CD158a is a member of the family of killer cell immunoglobulin-like receptors (KIRs) comprising transmembrane glycoproteins expressed on NK cells and a subset of T cells. Many groups of KIRs exist including KIR2DL1-2, KIR3DS1, KIR2DL1-5, and KIR2DS1-5. The isoforms have either a short (S) or long (L) cytoplasmic domain which transduce either an activating or inhibitory signal, respectively. The ligand for CD158a is HLA-C. The HP-MA4 antibody has been shown to not cross react with other KIRs, despite the conservation of sequence.

Details

Host	Mouse
Isotype	IgG2b
Reactivity	Human
Conjugate	PE-Cyanine7
Laser	Blue Laser, Green Laser, Yellow-Green Laser
Emit	775 nm
Excite	488 - 561 nm
Legal	FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT # 5,268,486, 5,569,587 AND 5,627,027 AND FOREIGN EQUIVALENTS AND PENDING APPLICATIONS. THIS MATERIAL IS SUBJECT TO PROPRIETARY RIGHTS OF GE HEALTHCARE BIO-SCIENCES CORP. AND CARNEGIE MELLON UNIVERSITY AND MADE AND SOLD UNDER LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. THIS PRODUCT IS LICENSED FOR SALE ONLY FOR RESEARCH. IT IS NOT LICENSED FOR ANY OTHER USE. THERE IS NO IMPLIED LICENSE HEREUNDER FOR ANY COMMERCIAL USE. COMMERCIAL USE shall include: 1. sale, lease, license or other transfer of the material or any material derived or produced from it; 2. sale, lease, license or other grant of rights to use this Material or any material derived or produced from it; 3. use of this material to perform services for a fee for third parties. IF YOU REQUIRE A COMMERCIAL LICENSE TO USE THIS MATERIAL AND DO NOT HAVE ONE, RETURN THIS MATERIAL, UNOPENED TO EBIOSCIENCE, INC. 10255 SCIENCE CENTER DRIVE, SAN DIEGO, CALIFORNIA 92121 USA AND ANY MONEY PAID FOR THE MATERIAL WILL BE REFUNDED.
Reported Applications	Flow Cytometric Analysis

Documentation

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
17-1589	Anti-Human CD158a APC	633 - 647 nm	660 nm	FC	RUO
45-1589	Anti-Human CD158a PerCP-Cyanine5.5	488 nm		FC	RUO
48-1589	Anti-Human CD158a eFluor® 450	405 nm	450 nm	FC	RUO
11-1589	Anti-Human CD158a FITC	488 nm		FC	RUO
12-1589	Anti-Human CD158a PE	488 - 561 nm		FC	RUO

Related Products

Cat. No.	Name	Excite	Emit	Application	Reg.
17-0567	Anti-Human CD56 (NCAM) APC	633 - 647 nm	660 nm	FC	RUO
25-4732	Mouse IgG2b K Isotype Control PE-Cyanine7	488 - 561 nm	775 nm	FC	RUO

References

References: Foley B, De Santis D, Lathbury L, Christiansen F, Witt C. KIR2DS1-mediated activation overrides NKG2A-mediated inhibition in HLA-C C2-negative individuals. Int Immunol. 2008 Apr;20(4):555-63.

M. De Miguel, M. Lopez-Botet, Characterization of monoclonal antibodies specific for receptors of the KIR family. Inmunologia 21: 2002; 187-193 (HP-MA4, FC, IP)

View More Products

Antigens	Area of Biology	Cell Type	Formats
CD158f	Innate Immunity	NK & NKT Cells	PE-Cyanine7