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Staining of the U937 cell line with Mouse IgG1 kappa Isotype Control PE (cat. 12-4714) (open...View More
Description: The monoclonal antibody 2H7CD155 recognizes CD155 also known as the poliovirus receptor. The CD155 protein is a member of the Ig superfamily in which 4 isoforms exist; only the α and δ forms are expressed on the membrane of monocytes and prostate cancer cells and neurectodermal and monocytic tumor cells lines. In addition CD155 is found during mid-gastrulation during embryonic development. CD155 is thought to play a role in adhesion by interaction with the ECM component vitronectin as well as a role in NK killingof tumor cells. CD226 and CD96 are ligands for CD155. Blocking of CD155 is under therapeutic investigation for prevention of variants of poliovirus.
References: Suzuki K, Nakamura K, Kato K, Hamada H, Tsukamoto T. Exploration of target molecules for prostate cancer gene therapy.Prostate. 2007 Aug 1;67(11):1163-73. (2H7CD155, FC, IP PubMed)
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