Anti-Human CD154 (CD40 Ligand) Functional Grade Purified

Also known as: CD40L, Tnfsf5, TRAP

Clone: 24-31

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 16-1548

Cat. No. Size
16-1548-82 100 ug
Please inquire about custom configurations or bulk packaging.

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Data for Anti-Human CD154 (CD40 Ligand) Functional Grade Purified.

Description

Description: The 24-31 monoclonal antibody reacts with human CD154, a 39 kDa transmembrane glycoprotein also known as gp39 and CD40 ligand (CD40L). CD154 is a member of the TNF superfamily and is expressed transiently by activated T cells. Through its binding to CD40 on antigen presenting cells including B cells, monocytes/macrophages and dendritic cells, CD154 serves a crucial function in T-APC cognate interaction. CD154 interaction with CD40 transduces signals for T-dependent B-cell activation and induces B cell cycle entry. 24-31 cross-reacts with the cynomolgus monkey CD154.

Details
Host Mouse
Isotype IgG1, kappa
Reactivity Human
Conjugate Functional Grade Purified (low endotoxin, azide-free)
Reported Applications Flow Cytometric Analysis, Functional Assays
Documentation
TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
46-1548 Anti-Human CD154 (CD40 Ligand) PerCP-eFluor® 710 488 nm 710 nm FC RUO
12-1548 Anti-Human CD154 (CD40 Ligand) PE 488 - 561 nm 575 nm FC RUO
11-1548 Anti-Human CD154 (CD40 Ligand) FITC 488 nm 518 nm FC RUO
17-1548 Anti-Human CD154 (CD40 Ligand) APC 633 - 647 nm 660 nm FC RUO
14-1548 Anti-Human CD154 (CD40 Ligand) Purified FC, FA RUO
48-1548 Anti-Human CD154 (CD40 Ligand) eFluor® 450 405 nm 450 nm FC RUO
47-1548 Anti-Human CD154 (CD40 Ligand) APC-eFluor® 780 633 - 647 nm 780 nm FC RUO
Related Products
Cat. No. Name Excite Emit Application Reg.
16-4714 Mouse IgG1 K Isotype Control Functional Grade Purified FC RUO
References

References: Brams, P., A. Black, et al. 2001. A humanized anti-human CD154 monoclonal antibody blocks CD154-CD40 mediated human B cell activation. Int Immunopharmacol 1(2): 277-94.