Anti-Human CD144 (VE-Cadherin) Biotin

Description: The 16B1 antibody reacts with human CD144, also known as VE-cadherin and cadherin-5. The cadherin family of receptors, which are calcium-dependent adhesion molecules, is known to be involved in homophilic cell interactions. VE-cadherin, which is 140 kDa, is localized at the intercellular boundaries of endothelial cells in blood and lymphatic vessels in several tissues. It is thought to play a role in vascular permeability and remodeling.

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Breviario F, Caveda L, Corada M, Martin-Padura I, Navarro P, Golay J, Introna M, Gulino D, Lampugnani MG, and Dejana E. 1995. Functional properties of human vascular endothelial cadherin (7B4/Cadherin-5), an endothelium-specific cadherin. Arterioscler Thromb Vasc Biol 15: 1229-1239.

Vincent PA, Xiao K, Buckley KM, and Kowalczyk AP. 2004. VE-Cadherin: adhesion at arm's length. Am J Physiol Cell Physiol 286: 987-997.