Anti-Human CD138 (Syndecan-1) APC

Description: The DL-101 monoclonal antibody reacts with human CD138, also known as syndecan-1. CD138 is a transmembrane protein containing chondroitin sulfate and heparin sulfate moieties responsible for binding to the extracellular matrix components. CD138 is not expressed by mature B cells but is present on pre-B cells and the finally differentiated plasma cells.

References: Fitzgerald ML, Wang Z, Park PW, Murphy G, Bernfield M. Shedding of Syndecan-1 and -4 Ectodomains Is Regulated by Multiple Signalling Pathways and Mediated by a TMIP-3 Metalloproteinase. J Cell Biol. 2000 Feb 21;148(4):811-24.

Kainulainen V, Wang H, Schick C, Bernfield M. Syndecans, Heparan Sulfate Proteoglycans, Maintain the Proteolytic Balance of Wound Fluids. J Biol Chem. 1998 May 8;273(19):11563-9.