Anti-Human CD131 PE

Description: The 1C1 monoclonal antibody reacts with the human CD131 molecule, also known as the common β subunit (β_C). The common β subunit associates with the specific α subunits of IL-3 receptor, IL-5 receptor and GM-CSF receptor to form high affinity receptors for these cytokines. These cytokine receptors are expressed by neutrophils, eosinophils, monocytes, endothelial cells, fibroblasts and hematopoietic progenitor cells and play a crucial role in growth/activation of eosinophils and in the inflammatory response.

References:
Sun, Q., K. Jones, et al. (1999). Simultaneous antagonism of interleukin-5, granulocyte-macrophage colony-stimulating factor, and interleukin-3 stimulation of human eosinophils by targetting the common cytokine binding site of their receptors. Blood 94(6): 1943-51.
Woodcock, J. M., B. J. McClure, et al. (1997). The human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor exists as a preformed receptor complex that can be activated by GM-CSF, interleukin-3, or interleukin-5. Blood 90(8): 3005-17.
Lopez, A. F., M. A. Vadas, et al. (1991). Interleukin-5, interleukin-3, and granulocyte-macrophage colony-stimulating factor cross-compete for binding to cell surface receptors on human eosinophils. J Biol Chem 266(36): 24741-7.