Anti-Human CD130 Functional Grade Purified

Description: The AN-HH1 monoclonal antibody reacts with human gp130, also known as CD130. gp130 is the common receptor subunit for the IL-6 family of cytokines, including IL-6, IL-11, IL-27, Oncostatin M, and LIF. gp130 is expressed on numerous cell types, including T cells, mast cells, and epithelial cells. Soluble forms of gp130 have been isolated from human serum samples. Upon ligand binding, gp130 signals via the JAK-STAT, MAPK, and PI3 kinase pathways. AN-HH1 is reported to neutralize the proliferative responses to LIF (leukemia inhibitory factor), CT-1 (cardiotrophin-1), OSM (oncostatin M), CLC (cardiotrophin-like cytokine), Interleukin (IL)-6, IL-11, and CNTF (ciliary neurotrophic factor), and neuropoietin.

References: Derouet D, Rousseau F, Alfonsi F, Froger J, Hermann J, Barbier F, Perret D, Diveu C, Guillet C, Preisser L, Dumont A, Barbado M, Morel A, deLapeyrière O, Gascan H, Chevalier S. Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor. Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4827-32. (AN-HH1, neutralizing, Pumbed)

Plun-Favreau H, Perret D, Diveu C, Froger J, Chevalier S, Lelièvre E, Gascan H, Chabbert M. Leukemia inhibitory factor (LIF), cardiotrophin-1, and oncostatin M share structural binding determinants in the immunoglobulin-like domain of LIF receptor. J Biol Chem. 2003 Jul 18;278(29):27169-79. (AN-HH1, FC, Pubmed)

Plun-Favreau H, Elson G, Chabbert M, Froger J, deLapeyrière O, Lelièvre E, Guillet C, Hermann J, Gauchat JF, Gascan H, Chevalier S. The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine. EMBO J. 2001 Apr 2;20(7):1692-703. (AN-HH1, neutralizing, Pubmed)

Narazaki M, Yasukawa K, Saito T, Ohsugi Y, Fukui H, Koishihara Y, Yancopoulos GD, Taga T, Kishimoto T. Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130. Blood. 1993 Aug 15;82(4):1120-6.