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Anti-Human CD126 PerCP-eFluor® 710

Also known as: Interleukin-6 Receptor alpha, IL-6Ra

Clone: 47.7G7.1F2

RUO: For Research Use Only. Not for use in diagnostic procedures.

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SKU# 46-1269

Cat. No. Size
46-1269-41 25 tests
46-1269-42 100 tests

Data for Anti-Human CD126 PerCP-eFluor® 710.

Staining of normal human peripheral blood cells with Anti-Human CD3 FITC (cat. 11-0037) and Mouse...View More

  • Data for Anti-Human CD126 PerCP-eFluor® 710.
Description

Description: This monoclonal antibody 47.7G7.1F2 reacts with human CD126, also known as IL-6 receptor alpha. It associates with the gp130 chain to form the high-affinity receptor for IL-6. Although gp130 is ubiquitously expressed, CD126 is only found on mature T cells, activated B cells, macrophages, hepatocytes, and myeloma cells. Upon binding to IL-6, two heterotrimeric complexes of receptor and ligand associate into a hexamer and are then internalized, initializing Jak/STAT signaling pathways. IL-6 induces the proliferation and survival of T cells, Th2 differentiation, and acute-phase protein production in the liver. A soluble form of CD126 lacking the transmembrane domain is also present and can be generated by cleavage at the cell surface or alternative splicing. Soluble CD126 can bind IL-6 and activate cells expressing only gp130 through trans-presentation.

Details
Host Mouse
Isotype IgG1, kappa
Reactivity Human
Conjugate PerCP-eFluor 710
Laser Blue Laser
Emit 710 nm
Excite 488 nm
Reported Applications Flow Cytometric Analysis
Documentation
TDS Link Download TDS
Related Products
Cat. No. Name Excite Emit Application Reg.
12-1261 Anti-Mouse CD126 PE 488 - 561 nm 578 nm FC RUO
BMS214* Human sIL-6R Platinum ELISA ELISA RUO
11-0037 Anti-Human CD3 FITC 488 nm 520 nm FC RUO
46-4714 Mouse IgG1 K Isotype Control PerCP-eFluor® 710 488 nm 710 nm FC RUO
References

References: Dienz O, Rincon M. The effects of IL-6 in CD4 T cell responses. Clin Immunol. 2009 Jan; 130(1): 27-33.

Fujimoto M, Serada S, Mihara M, Uchiyama Y, Yoshida H, Koike N, Ohsugi Y, Nishikawa T, Ripley B, Kimura A, Kishimoto T, Naka T. Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses. Arthritis Rheum. 2008 Dec; 58(12): 3710-9.

Rawstron AC, Fenton JA, Ashcroft J, English A, Jones RA, Richards SJ, Pratt G, Owen R, Davies FE, Child JA, Jack AS, Morgan G. The interleukin-6 receptor alpha-chain (CD126) is expressed by neoplastic but not normal plasma cells. Blood. 2000 Dec 1; 96(12): 3880-6.

Betz UA, Muller W. Regulated expression of gp130 and IL-6 receptor alpha chain in T cell maturation and activation. Int Immunol. 1998 Aug; 10(8): 1175-84.