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Anti-Human CD126 PerCP-eFluor® 710

Also known as: Interleukin-6 Receptor alpha, IL-6Ra

Clone: 47.7G7.1F2

RUO: For Research Use Only. Not for use in diagnostic procedures.

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SKU# 46-1269

Cat. No. Size
46-1269-41 25 tests
46-1269-42 100 tests

Data for Anti-Human CD126 PerCP-eFluor® 710.

Staining of normal human peripheral blood cells with Anti-Human CD3 FITC (cat. 11-0037) and Mouse...View More

  • Data for Anti-Human CD126 PerCP-eFluor® 710.

Description: This monoclonal antibody 47.7G7.1F2 reacts with human CD126, also known as IL-6 receptor alpha. It associates with the gp130 chain to form the high-affinity receptor for IL-6. Although gp130 is ubiquitously expressed, CD126 is only found on mature T cells, activated B cells, macrophages, hepatocytes, and myeloma cells. Upon binding to IL-6, two heterotrimeric complexes of receptor and ligand associate into a hexamer and are then internalized, initializing Jak/STAT signaling pathways. IL-6 induces the proliferation and survival of T cells, Th2 differentiation, and acute-phase protein production in the liver. A soluble form of CD126 lacking the transmembrane domain is also present and can be generated by cleavage at the cell surface or alternative splicing. Soluble CD126 can bind IL-6 and activate cells expressing only gp130 through trans-presentation.

Host Mouse
Isotype IgG1, kappa
Reactivity Human
Conjugate PerCP-eFluor 710
Laser Blue Laser
Emit 710 nm
Excite 488 nm
Reported Applications Flow Cytometric Analysis
TDS Link Download TDS
Related Products
Cat. No. Name Excite Emit Application Reg.
12-1261 Anti-Mouse CD126 PE 488 - 561 nm 578 nm FC RUO
BMS214* Human sIL-6R Platinum ELISA ELISA RUO
11-0037 Anti-Human CD3 FITC 488 nm 520 nm FC RUO
46-4714 Mouse IgG1 K Isotype Control PerCP-eFluor® 710 488 nm 710 nm FC RUO

References: Dienz O, Rincon M. The effects of IL-6 in CD4 T cell responses. Clin Immunol. 2009 Jan; 130(1): 27-33.

Fujimoto M, Serada S, Mihara M, Uchiyama Y, Yoshida H, Koike N, Ohsugi Y, Nishikawa T, Ripley B, Kimura A, Kishimoto T, Naka T. Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses. Arthritis Rheum. 2008 Dec; 58(12): 3710-9.

Rawstron AC, Fenton JA, Ashcroft J, English A, Jones RA, Richards SJ, Pratt G, Owen R, Davies FE, Child JA, Jack AS, Morgan G. The interleukin-6 receptor alpha-chain (CD126) is expressed by neoplastic but not normal plasma cells. Blood. 2000 Dec 1; 96(12): 3880-6.

Betz UA, Muller W. Regulated expression of gp130 and IL-6 receptor alpha chain in T cell maturation and activation. Int Immunol. 1998 Aug; 10(8): 1175-84.