Anti-Human CD123 Biotin

Description: The 6H6 monoclonal antibody reacts with human CD123, the α chain of the IL-3 receptor. This 60-70 kDa transmembrane protein binds to IL-3 with low affinity by itself, and when associated with CD131 (common β chain) binds IL-3 with high affinity. CD123 is expressed by myeloid precursors, macrophages, dendritic cells, mast cells, basophils, and megakaryocytes.

References:
Herling, M., M. Teitell, R. Shen, L. Medeiros, and D. Jones. 2003. TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin. Blood. 101: 5007-5009.

Jaye, D.L., C.M. Geigerman, et al. 2006. Expression of the plasmacytoid dendritic cell marker BDCA-2 supports a spectrum of maturation among CD4+CD56+ hematodermic neoplasms. Mod Pathol. 19(12): 1555-62. (IHC paraffin PubMed)

Peduzzi, E., C. Groeper, et al. 2007. Local activation of the innate immune system in Buruli Ulcer lesions. J Invest Dermatol. 127(3) :638-45. (IHC paraffin PubMed)

Assaf C., S. Gellrich, et al. 2007. CD56 lymphoproliferative disorders of the skin: A multicenter study of the cutaneous lymphoma project group of the european organization for research and greatment of cancer (EORTC). J Clin Pathol. 60(9): 981-9. (IHC frozen PubMed)

Xu. W., B. He, et al. 2007. Epithelial cells trigger frontline immunoglobulin class switching through a pathway regulated by the inhibitor SLP1. Nature Immunol. 8(3): 294-303. (IHC frozen PubMed)