Anti-Human CD11a Functional Grade Purified

Description: The HI111 monoclonal antibody reacts with human CD11a, the 180 kDa integrin α_L, also known as the lymphocyte function associated antigen-1 (LFA-1) α chain. LFA-1, formed by non-covalent association of CD11a with CD18 (integrin β₂), serves as an important adhesion molecule involved in lymphocyte and granulocyte function. CD54 (ICAM-1), CD102 (ICAM-2), and CD50 (ICAM-3) are ligands for LFA-1. CD11a is expressed by all leukocytes.

References: Kapsogeorgou EK, Dimitriou ID, Abu-Helu RF, Moutsopoulos HM, Manoussakis MN. Activation of epithelial and myoepithelial cells in the salivary glands of patients with Sjögren's syndrome: high expression of intercellular adhesion molecule-1 (ICAM.1) in biopsy specimens and cultured cells. Clin Exp Immunol. 2001 Apr;124(1):126-33. (HI111, IHC frozen)

Knapp, W., B. Dorken, et al. eds 1989. Leucocyte Typing IV: White Cell Differentiation Antigens. Oxford University Press. New York.