Anti-Human CD116 Biotin

Description: The 4H1 monoclonal antibody reacts with the human CD116 molecule, the α subunit of GM-CSF receptor. The α subunit associates with the common β chain (CD131) to form the high affinity receptor for GM-CSF. The GM-CSFR α chain is expressed by granulocytes, monocytes, endothelial cells, fibroblasts and some tumor cells.

References:
Sun, Q., K. Jones, et al. (1999). Simultaneous antagonism of interleukin-5, granulocyte-macrophage colony-stimulating factor, and interleukin-3 stimulation of human eosinophils by targetting the common cytokine binding site of their receptors. Blood 94(6): 1943-51.
Woodcock, J. M., B. J. McClure, et al. (1997). The human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor exists as a preformed receptor complex that can be activated by GM-CSF, interleukin-3, or interleukin-5. Blood 90(8): 3005-17.
Lopez, A. F., M. A. Vadas, et al. (1991). Interleukin-5, interleukin-3, and granulocyte-macrophage colony-stimulating factor cross-compete for binding to cell surface receptors on human eosinophils. J Biol Chem 266(36): 24741-7.