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Anti-Human CD104 (Integrin beta 4) Biotin

Also known as: Integrin b4, ITGB4

Clone: 439-9B

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 13-1049

Cat. No. Size
13-1049-80 25 ug
13-1049-82 100 ug
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Data for Anti-Human CD104 (Integrin beta 4) Biotin.

Staining of the A549 cell line with 0.125 ug of Rat IgG2b K Isotype Control Biotin (cat. 13-4031)...View More

  • Data for Anti-Human CD104 (Integrin beta 4) Biotin.
Description

Description: The monoclonal antibody 439-9B recognizes human CD104, also known as integrin beta 4. CD104 is a 202 kDa subunit that associates with integrin alpha 6 (CD49f), thereby forming the laminin receptor. Multiple splice variants have been identified. Expression is found on epithelial cells and tumor cells and has been shown to be involved in cell-matrix and cell-cell interactions. The role of CD104 in tumorigenicity is well established. The monoclonal antibody 439-9B has been reported to have no effect on adhesion of human colon adenocarcinoma cells. Moreover, this antibody crossreacts to bovine.

Details
Host Rat
Isotype IgG2b
Reactivity Human
Conjugate Biotin
Reported Applications Flow Cytometric Analysis, Immunohistochemical Staining of Frozen Tissue Sections, Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections
Documentation
TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
14-1049 Anti-Human CD104 (Integrin beta 4) Purified FC, IHC, IP, WB RUO
50-1049 Anti-Human CD104 (Integrin beta 4) eFluor® 660 (Alexa Fluor® 647 Replacement) 633 - 647 nm 668 nm FC, IHC RUO
Related Products
Cat. No. Name Excite Emit Application Reg.
12-4317 Streptavidin PE 488 - 561 nm FC RUO
13-4031 Rat IgG2b K Isotype Control Biotin FC, ICC, IHC RUO
References

References: Simon-Assmann P, Leberquier C, Molto N, Uezato T, Bouziges F, Kedinger M. Adhesive properties and integrin expression profiles of two colonic cancer populations differing by their spreading on laminin. J Cell Sci. 1994 Mar;107 ( Pt 3):577-87.(439-9B, IP, PubMed)

Falcioni R, Sacchi A, Resau J, Kennel SJ. Monoclonal antibody to human carcinoma-associated protein complex: quantitation in normal and tumor tissue. Cancer Res. 1988 Feb 15;48(4):816-21. (439-9B, IP, WB, PubMed)

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