Anti-Human CD103 (Integrin alpha E) PE

Description: The B-Ly7 monoclonal antibody reacts with human CD103, the α_E integrin. CD103 non-covalently associates with integrin β₇. CD103 is expressed mainly on intraepithelial lymphocytes and a small subset of peripheral lymphocytes. CD103 is also expressed by hairy cell leukemia (HCL) and by some chronic B cell lymphocytic leukemias. In vitro stimulation of human T cells with mitogens induces upregulation of CD103. Epithelial cell antigen, E-cadherin, binds to CD103 and mediates homing of lymphocytes to the intestinal epithelium.

References: de Harven E, Soligo D, Christensen H. 1995. Immunogold labeling for the diagnosis of leukemia by transmission and scanning electron microscopy. Scanning Microsc. 9:1191-199

de Harven E, Christensen H, Poppema S, Scott JG. 1994. Immunogold labelling of leukemic hairy cells with the B-ly7 monoclonal antibody: an SEM and TEM study. Microsc Res Tech. 28:356-67

Visser L, Dabbagh L, Poppema S. 1992. Reactivity of monoclonal antibody B-ly7 with a subset of activated T cells and T-cell lymphomas. Hematol Pathol. 6:37-42

Thaler J, Dietze O, Faber V, Greil R, Gastl G, Denz H, Ho AD, Huber H. 1990. Monoclonal antibody B-ly7: a sensitive marker for detection of minimal residual disease in hairy cell leukemia. Leukemia. 4:170-6

Schwarting R, Dienemann D, Kruschwitz M, Fritsche G, Stein H. 1990. Specificities of monoclonal antibodies B-ly7 and HML-1 are identical. Blood. 75:320-1.