Human CCL2 (MCP-1) Recombinant Protein

Also known as: Monocyte chemotactic protein 1

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 14-8398

Cat. No. Size
14-8398-62 5 ug
14-8398-80 25 ug
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Data for Human CCL2 (MCP-1) Recombinant Protein.

Description

Description: CCL2, also known as Monocyte Chemotactic Protein-1 (MCP-1) and Monocyte Chemotactic and Activating Factor (MCAF), is a member of the ß (CC) subfamily of chemokines. CCL2 is a chemoattractant for monocytes and regulates their adhesion molecule and cytokine expression patterns. It has also been shown to activate monocytes to be cytostatic for some human tumor cell lines. CCL2 is also capable of chemoattracting, activating and inducing histamine release from basophils. Recombinant human CCL2 produced inE. coli is a non-glycosylated peptide chain of 76 amino acids.

Details
Reactivity Human
Purity Greater than 98%, as determined by SDS-PAGE
Molecular Mass 8.6 kDa
Endotoxin Level Less than 0.01 ng/ug cytokine as determined by the LAL assay.
Reported Applications Cytokine Bioassays
Documentation
TDS Link Download TDS
Related Products
Cat. No. Name Excite Emit Application Reg.
14-7091 Anti-Mouse CCL2 (MCP-1) Purified ELISA RUO
14-7096 Anti-CCL2 (MCP-1) Purified FC, ELISA, IHC, WB RUO
14-7099 Anti-Human CCL2 (MCP-1) Purified FC, ELISA, IHC, IP RUO
References

References: Wang L, Yang L, Gao L, Gao TW, Li W, Liu YF. A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with psoriasis. Int J Immunogenet. 2008 Feb;35(1):45-9. (ELISA, PubMed)

Arlian LG, Morgan MS, Peterson KT. House dust and storage mite extracts influence skin keratinocyte and fibroblast function. Int Arch Allergy Immunol. 2008;145(1):33-42. (ELISA, PubMed)

Fouts AE, Boothroyd JC. Infection with Toxoplasma gondii bradyzoites has a diminished impact on host transcript levels relative to tachyzoite infection. Infect Immun. 2007 Feb;75(2):634-42. (ELISA, PubMed)

Kohwiwattanagun J, Kawamura I, Fujimura T, Mitsuyama M. Mycobacterial mammalian cell entry protein 1A (Mce1A)-mediated adherence enhances the chemokine production by A549 alveolar epithelial cells. Microbiol Immunol. 2007;51(2):253-61. (ELISA, PubMed)