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Anti-Human CCL5 (RANTES) Alexa Fluor® 647

Also known as: CCL-5, regulated upon activation normal T-cell expressed, and presumably secreted, SIS-delta, SCYA5

Clone: VL1

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 51-9905

Cat. No. Size
51-9905-41 25 tests
51-9905-42 100 tests
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Data for Anti-Human CCL5 (RANTES) Alexa Fluor® 647.

Normal human peripheral blood cells were treated for 5 hours with Monensin, surface stained with...View More

  • Data for Anti-Human CCL5 (RANTES) Alexa Fluor® 647.
Description

Description: The VL1 monoclonal antibody reacts with human CCL5/RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted). RANTES is an 8 kDa member of the C-C chemokine family. Although rapidly induced in fibroblasts and epithelial cells, RANTES is upregulated only after 3-5 days of activation in T cells. As with other members of the C-C chemokine family, RANTES is a strong chemotractant for monocytes, NK cells, eosinophils and T cells. RANTES is also expressed by monocytes upon activation and has recently been reported to be constitutively expressed by NK cells.

Details
Host Mouse
Isotype IgG2b, kappa
Reactivity Human
Conjugate Alexa Fluor 647
Laser Red Laser
Emit 668 nm
Excite 633 nm
Legal Alexa Fluor® and Pacific Blue® are registered trademarks of and licensed under patents assigned to Molecular Probes, Inc. for research use only. This product is subject to an agreement between Molecular Probes, Inc. and eBioscience, and the manufacture, use, sale or import of this product may be subject to one or more U.S. patents, pending applications and corresponding foreign equivalents, owned by Molecular Probes, Inc. (a wholly owned subsidiary of Invitrogen Corp). The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product for life science research or as an ASR. The buyer cannot use this product for manufacturing or for any other screening (specifically including use in combination with microarrays or High Content Screening) or testing purpose, other than as an ASR. For information on purchasing a license to this product for purposes other than life science research or use as an ASR, contact Molecular Probes, Inc.
Reported Applications Intracellular Staining Followed by Flow Cytometric Analysis
Documentation

For complete product information, please download the TDS or IFU document.

TDS Link Download TDS
Additional Formats
References

References: Kumar D, Hosse J, von Toerne C, Noessner E, Nelson PJ. JNK MAPK pathway regulates constitutive transcription of CCL5 by human NKcells through SP1. J Immunol. 2009 Jan 15;182(2):1011-20. (VL1, IC Flow, IF, Pubmed)

Krensky AM, Nelson PJ. Expression of chemokine RANTES and production of monoclonal antibodies. Methods Enzymol. 1997;287:162-74. (VL1, Pubmed)

Ortiz BD, Nelson PJ, Krensky AM. Switching gears during T-cell maturation: RANTES and late transcription. Immunol Today. 1997 Oct;18(10):468-71.

Schall TJ. Biology of the RANTES/SIS cytokine family. Cytokine. 1991 May;3(3):165-83.

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