Anti-Human Calcineurin Purified

Description: This BE2.1 monoclonal antibody reacts with human calcineurin, which is also known as protein phosphatase 2B. Calcineurin is a calcium- and calmodulin-dependent serine/threonine phosphatase that is composed of a 59-kDa catalytic subunit (Calcineurin A) and a 19-kDa regulatory subunit (Calcineurin B). This enzyme is expressed in all tissues in mammals. In the immune system, calcineurin plays a key role in T cell activation by dephosphorylating NFAT and thereby enabling the transcription factor to translocate into the nucleus to promote expression of genes such as IL-2. The activity of calcineurin can be inhibited by the immunosuppressants FK506 and cyclosporin A. Dysfunctional calcineurin regulation has been implicated in a variety of immune and non-immune diseases, including diabetes, asthma, and Alzheimer’s disease.

This monoclonal antibody recognizes the 59-kDa Calcineurin A subunit.

References: Crabtree GR, Schreiber SL. SnapShot: Ca2+-calcineurin-NFAT signaling. Cell. 2009 Jul 10;138(1):210.

Clipstone NA, Crabtree GR. Calcineurin is a key signaling enzyme in T lymphocyte activation and the target of the immunosuppressive drugs cyclosporin A and FK506. Ann N Y Acad Sci. 1993 Nov 30;696:20-30.

Bram RJ, Hung DT, Martin PK, Schreiber SL, Crabtree GR. Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location. Mol Cell Biol. 1993 Aug;13(8):4760-9.

McCaffrey PG, Perrino BA, Soderling TR, Rao A. NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs. J Biol Chem. 1993 Feb 15;268(5):3747-52.

Clipstone NA, Crabtree GR. Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature. 1992 Jun 25;357(6380):695-7.