SAFE™ Cytokines and Growth Factors
Serum and Animal-Free, low Endotoxin
The SAFE (Serum and Animal-Free, low Endotoxin) system uses barley endosperm storage cell, characterized by its biochemically inert environment and lack of endotoxins, as the production host. Further advantages of this system include low protease activity and secondary metabolite content and simple protein content, all of which aid in downstream processing.
Plant expression produces recombinant proteins with highly complex 3D structures in the same way mammalian cell cultures do, including disulfide bonds and other post-translational modification resulting in proteins that are as active as their counterparts produced in CHO or similar expression systems