Product Information

Contents: betaCatenin (C18) Blocking Peptide
Catalog Number: 66-P765
Sizes: 50 ug
Formulation: Each vial contains 100 μg of peptide in 0.5 ml PBS with 0.1% NaN₃ and 100 μg BSA.
Storage Conditions: Store at 4°C.
DO NOT FREEZE.

Available Formats of This Product
Cat. No.	Format	Excite (nm)	Emit (nm)	Reported Applications
66-P765	Blocking Peptides for anti-mouse/human/rat beta-Catenin polyclonal	N/A	N/A	WB

Questions? Please consult our answers to frequently asked questions at http://www.ebioscience.com/faq.

Description

This is a peptide mapping to the carboxy terminal domain of human beta-catenin. The multifunctional beta-catenin protein was originally identified through its association with the cadherin class of cell adhesion proteins (1&2). It was later found to be an integral part of signal transduction pathways and the best studied is the Wnt/beta-catenin pathway (3). Wnt signaling inhibits the degradation of beta-catenin and as a result beta-catenin becomes transcriptionally active (3-5). The deregulation of Wnt signaling leads to the accumulation of beta-catenin, allowing it to become transcriptionally active for a number of genes. Many of these genes are associated with cancer, such as colorectal cancer and melanomas (3&4).

Applications Reported

For research use only, not for diagnostic or therapeutic use. This blocking peptide has been reported for use in competition studies.

References

1. Hinck L, Nathke IS, Papkoff J, Nelson WJ. 1994. ?-catenin: a common target for the regulation of cell adhesion by Wnt-1 and Src signaling pathways. Trends Biochem Sci. 19(12):538-542.
2. Bullions LC, Levine AJ. 1998. The role of ?-catenin in cell adhesion, signal transduction, and cancer. Curr Opin Oncol. 10(1):81-87.
3. Moon RT, Bowerman B, Boutros M, Perrimon N. 2002. The promise and perils of Wnt signaling through ?-catenin. Science 296(5573):1644-1646.
4. Li H, Pamukcu R, Thompson WJ. 2002. ?-catenin signaling: therapeutic strategies in oncology. Cancer Biol Ther. (6):621-625.
5. Hecht A, Kemler R. 2000. Curbing the nuclear activities of ?-catenin. Control over Wnt target gene expression. EMBO 1(1):24-28.

Related Products

Cat. 14-6765 Purified anti-mouse/human/rat beta-Catenin polyclonal (clone Polyclonal)