Product Information

Contents: Blocking peptide for human DR6
Catalog Number: 66-6622
Storage Conditions: This product is supplied
as Protein G purified IgG fraction in PBS
containing 0.02% sodium azide. Store at
4°C, stable for 6 months. For long-term
storage, store at –20°C.
Clone: 15A208
Isotype: Mouse IgG1

Description

The 15A208 antibody reacts with human DR6; the antibody was raised against the cytoplasmic domain (amino acids 371-655) of human DR6 protein.. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR6 (for death receptor 6). The extracellular domain of DR6 contains four TNFR-like cysteine rich motifs that are most related to those of osteoprotegerin (OPG) and TNFR2 with 36% and 42% amino acid identities, respectively. The death domain of DR6 (amino acids 428-494) located adjacent to the transmembrane domain is most related to TNFR1 (27.2%) and least to DR5 (19.7%).

Applications Reported

For research use only, not for diagnostic or therapeutic use.

References

Pan G, et al. FEBS Lett 431: 351-356 (1998).
Simonet WS, et al. Cell 89: 309-310 (1997).
Baker SJ, et al. Oncogene 12: 1-9 (1996).

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Cat. 60-6633 Polyclonal antibody to human DR6 (clone Polyclonal)