Product Information

Contents: Functional Grade Purified anti-human DR5, activating (CD262, Trail-R2, TrailR2)
Catalog Number: 16-9907
Sizes: 100 ug
Formulation: Phosphate buffer pH 7.2,
500 mM NaCl, No NaN₃
Storage Conditions: Store at 4°C.
Avoid repeated freeze/thaw cycles.
KEEP CONTENTS STERILE.
Endotoxin Level: Less than 0.01 ng/ug antibody, as determined by the LAL assay.
Clone: 2A7
Isotype: Mouse IgM, κ

Available Formats of This Product
Cat. No.	Format	Excite (nm)	Emit (nm)	Reported Applications
16-9907	Functional Grade* Purified anti-human DR5, activating (CD262, Trail-R2, TrailR2)	N/A	N/A	FA
*Functional Grade™ (FG™) Purified: Azide-free, sterile-filtered, and endotoxin < 0.001 ng/µg (unless otherwise noted). *Functional Grade™ (FG™) Biotin: Azide-free, sterile-filtered, and endotoxin < 0.05 ng/µg. Purified: Contains azide, not sterile-filtered, and not endotoxin tested.

Questions? Please consult our answers to frequently asked questions at http://www.ebioscience.com/faq.

Description

The monoclonal antibody reacts with human DR5, also known as TRAIL-R2, Apo2, TRICK2 and KILLER. DR5 binds to TRAIL, activates NF-kappaB, and induces TRAIL-mediated apoptosis. DR5 is expressed broadly by normal tissues as well as several tumor cell lines. This antibody is reported to have strong apoptosis-inducing activity.

Applications Reported

For research use only, not for diagnostic or therapeutic use.

Applications Tested

This 2A7 antibody has been tested by apoptotic induction of Jurkat cells.

References

Ichikawa K, Liu W, Fleck M, Zhang H, Zhao L, Ohtsuka T, Wang Z, Liu D, Mountz JD, Ohtsuki M, Koopman WJ, Kimberly R, and Zhou T. 2003. TRAIL-R2 (DR5) mediates apoptosis of synovial fibroblasts in rheumatoid arthritis. J Immunol. 171:1061-1069.

Ichikawa K, Liu W, Zhao L, Wang Z, Liu D, Ohtsuka T, Zhang H, Mountz JD, Koopman WJ, Kimberly RP, and Zhou T. 2001. Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocytic cytotoxicity. Nat Medicine. 7(8):954-960.

Related Products

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Cat. 13-9908    Biotin anti-human DR5 (CD262, Trail-R2, TrailR2) (clone DJR2-4 (a.k.a. 7-8))
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