Contents: Functional Grade Purified anti-human TNF-α
Catalog Number: 16-7348
Formulation: Phosphate buffer pH 7.2,
150 mM NaCl, No NaN3
Storage Conditions: Store at 4°C.
Avoid repeated freeze/thaw cycles.
KEEP CONTENTS STERILE.
Endotoxin Level: Less than 0.001 ng/ug antibody, as determined by the LAL assay.
Clone: MAb1
Isotype: Mouse IgG1, κ
| Prices for This Product* |
| Cat. No. |
Size |
Price |
Qty |
Action |
*International customers: Please contact your distributor for region specific pricing.
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| Available Formats of This Product |
| Cat. No. |
Format |
Excite
(nm) |
Emit
(nm) |
Reported Applications |
| 14-7348 |
Affinity Purified anti-human TNFa (Tumor Necrosis Factor alpha, TNF-alpha, TNF-a) |
N/A |
N/A |
ELISA cap
ELISPOT cap
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| 16-7348 |
Functional Grade* Purified anti-human TNFa (Tumor Necrosis Factor alpha, TNF-alpha, TNF-a) |
N/A |
N/A |
ELISA cap
ELISPOT cap
NU
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*Functional Grade™ (FG™) Purified: Azide-free, sterile-filtered, and endotoxin < 0.001 ng/µg (unless otherwise noted).
*Functional Grade™ (FG™) Biotin: Azide-free, sterile-filtered, and endotoxin < 0.05 ng/µg.
Purified: Contains azide, not sterile-filtered, and not endotoxin tested. |
Questions? Please consult our answers to frequently asked questions at
http://www.ebioscience.com/faq.
Description
The MAb1 antibody reacts with human tumor necrosis factor-alpha (TNF-α), a 17 kDa cytokine produced by monocytes, macrophages, neutrophils, NK cells and CD4
+ T cells. TNF-α has cytolytic activity against a range of tumor cells and is important in immune regulation. TNF-α forms dimers and trimers and also exists as a 26 kDa membrane bound form.
Applications Reported
For research use only, not for diagnostic or therapeutic use. The Mab1 antibody has been reported for use in ELISA, ELISPOT, intracellular staining and neutralization.
Applications Tested
The MAb1 antibody has been tested for neutralizing TNF-α binding and biological activity.
References
Danis, V. A., G. M. Franic, et al. (1991). "Effects of granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-2, interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha) and IL-6 on the production of immunoreactive IL-1 and TNF-alpha by human monocytes."
Clin Exp Immunol 85(1): 143-50.
Rathjen, D. A., K. Cowan, et al. (1991). "Antigenic structure of human tumour necrosis factor: recognition of distinct regions of TNF alpha by different tumour cell receptors."
Mol Immunol 28(1-2): 79-86.
Related Products
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16-4714 Functional Grade Purified Mouse IgG1, K Isotype Control
Cat.
13-7349 Biotin anti-human TNFa (Tumor Necrosis Factor alpha, TNF-alpha, TNF-a) (clone MAb11)
Cat.
14-8329 Recombinant Human TNFa (Tumor Necrosis Factor alpha, TNF-alpha, TNF-a)
