Contents: Affinity Purified anti-mouse/human Toll-like receptor 7 (TLR7, TLR-7)
Catalog Number: 14-9079
Formulation: Phosphate buffer pH 7.2,
150 mM NaCl, 0.09% NaN3
Storage Conditions: Store at 4°C.
Avoid repeated freeze/thaw cycles.
Clone: Polyclonal
Isotype: Rabbit IgG
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Description
The polyclonal antibody reacts with human and mouse TLR7 and was generated using 14 amino acid residues near the middle of mouse TLR7. To date, at least twelve members of the Toll family have been identified. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. In the innate immunity system, TLRs recognize molecular patterns associated with microbial pathogens and induce antimicrobial immune responses. TLR7, similar to TLR3, 8, and 9, is localized to endosomal/lysosomal compartments and is reported to respond to single-stranded RNA and some anti-viral compounds. Immunoblotting with this antibody gives a MW of ~120 kDa in Daudi cells.
Applications Reported
For research use only, not for diagnostic or therapeutic use. Rabbit anti-human, mouse TLR7 poly has been reported for use in immunoblotting (WB).
Applications Tested
Rabbit anti-human, mouse TLR7 poly has been tested by immunoblotting (WB) of Daudi cell lysates (1-2ug/ml). It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
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Mouse Cellular Antigens Chart
Human Cellular Antigens Chart