Contents: Affinity Purified rabbit anti-mouse interleukin-15 (IL-15)
Catalog Number: 14-7151
Storage Conditions: Store at 4°C.
Avoid repeated freeze/thaw cycles.
Contains 0.09% NaN3.
Clone: Polyclonal
Isotype: Rabbit IgG
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Description
The rabbit polyclonal antibody reacts with mouse IL-15. The antibody was generated using
E. coli expressed mouse IL-15 as an immunogen. IL-15 is a 14-15 kDa member of the four alpha-helical bundle family of cytokines. It is very similar to IL-2, except that IL-15 has an IL-15α receptor subunit. It plays an important role in the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes as well as activation of a number of important intracellular signaling molecules. This implies that IL-15 could be essential for the immune responses, allograft rejection, and the pathogenesis of autoimmune diseases.
Applications Reported
For research use only, not for diagnostic or therapeutic use. This polyclonal can be used in immunoblotting (WB). Cross-reactivity to IL-15 of other species has not been determined.
Applications Tested
The tested titer for Western blot is 1:5000.
References
Cosman, D, et al. 1995. Interleukin 15 and its receptor. Ciba Found Symp 1955:221-9
Waldmann, T, et al. 1998. Interleukin-2, interleukin-15 and their receptors. Int Rev Immunol 16 (3-4): 205-26
Kennedy, MK, et al. 1996. Characterization of interleukin-15 (IL-15) and the IL-15 receptor complex. J Clin Immunol 16 (3): 134-43
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