Contents: Polyclonal anti-human, mouse, rat RICK (C-terminus)
Catalog Number: 14-6232
Formulation: This product is supplied as purified rabbit IgG fraction in PBS containing 0.02% NaN3.
Storage Conditions: Store at 4°C, stable for 6 months. Stable at –20°C for one year. Avoid multiple freeze/thaw cycles.
Clone: Polyclonal
Isotype: Rabbit IgG
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Description
The polyclonal antibody reacts with human, mouse, and rat RICK; the antibody was raised against residues 508-522 of human RIP-like interacting CLARP kinase (RICK), otherwise known as Receptor Interacting Protein-2 (RIP2), and CARD-containing ICE associated kinase (CARDIAK). RICK contains an N-terminal kinase catalytic domain and a C-terminal CARD domain. Overexpression of RICK induces apoptosis and activation of NF-κB and JNK. RICK interacts with members of the TRAF family, CLARP and caspase-1. It regulates TNF and Fas induced-apoptosis and is involved in the generation of proinflammatory cytokine IL-1β. The mRNA of RICK is expressed in multiple human tissues.
Applications Reported
For research use only, not for diagnostic or therapeutic use. This polyclonal antibody has been reported for use in immunoblotting (WB) and reacts with human, mouse, and rat RICK.
References
Inohara N, del Peso L, Koseki T, Chen S, Nunez G. RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis.
J Biol Chem 1998;273:12296-300.
McCarthy JV, Ni J, Dixit VM. RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.
J Biol Chem 1998;273:16968-75.
Thome M, Hofmann K, Burns K, Martinon F, Bodmer JL, Mattmann C, Tschopp J. Identification of CARDIAK, a RIP-like kinase that associates with caspase-1.
Curr Biol 1998;8:885-8.
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