14-6171

Contents: Anti-human Bonzo (STRL33) NT2 Polyclonal
Catalog Number: 14-6171
Formulation: This product is supplied as purified rabbit IgG in PBS containing 0.02% NaN₃
Storage Conditions: Store at 4°C, stable for one year. Avoid repeated freeze/thaw cycles.
Clone: Polyclonal

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Cat. No.	Format	Excite (nm)	Emit (nm)	Reported Applications

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Description

The rabbit anti-human Bonzo polyclonal antibody was raised against a peptide corresponding to amino acids 11 to 25 of human Bonzo/STRL33. The sequence of this peptide differs from those of African green monkey and pig-tailed macaque by one or two amino acids, respectively. Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, and CCR2b in the chemokine receptor family have been identified as HIV coreceptors. An orphan G protein-coupled receptor was recently cloned and designated Bonzo, STRL33 and TYMSTR, and identified as HIV and SIV coreceptor. Bonzo/STRL33 serves as coreceptor for SIV, HIV-2 and HIV-1. The messenger RNA of Bonzo/STRL33 is expressed in lymphoid tissues and activated peripheral blood lymphocytes.

Applications Reported

For research use only, not for diagnostic or therapeutic use. This polyclonal antibody has been reported for use in immunoblotting (WB).

Applications Tested

This polyclonal antibody has been tested by immunoblotting (WB) with a recommended 1:500 dilution. Human spleen tissue lysate can be used as positive control. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

References

Loetscher M, Amara A, Oberlin E, Brass N, Legler D, Loetscher P, D'Apuzzo M, Meese E, Rousset D, Virelizier JL, Baggiolini M, Arenzana-Seisdedos F, Moser B. 1997. TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function. Curr Biol. Sep 1;7(9):652-60.
Alkhatib G, Liao F, Berger EA, Farber JM, Peden KW. 1997. A new SIV co-receptor, STRL33. Nature. Jul 17;388(6639):238.
Liao F, Alkhatib G, Peden KW, Sharma G, Berger EA, Farber JM. 1997. STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1. J Exp Med. Jun 2;185(11):2015-23.
Deng HK, Unutmaz D, KewalRamani VN, Littman DR. 1997. Expression cloning of new receptors used by simian and human immunodeficiency viruses. Nature. Jul 17;388(6639):296-300.