Contents: Anti-mouse/human/rat Stat5α (C-terminus) polyclonal
Catalog Number: 14-6115
Storage Conditions: This product is supplied as 1 mg/ml purified rabbit IgG fraction in PBS containing 0.2% BSA and 0.09% NaN3. Store at 4°C, stable for 12 months. Avoid multiple freeze/thaw cycles.
Clone: Polyclonal
Isotype: Rabbit IgG
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Description
The polyclonal antibody reacts with human, mouse, and rat Stat5α; the antibody has been generated against the C-terminus of human Stat5α. Stat5α protein is a transcription factor activated by hormone and cytokines. Two highly related, but distinct Stat5 genes (Stat5α and Stat5β) were identified in mouse. The amino acid sequences of Stat5α and Stat5β show ~96% sequence similarity, and both proteins are co-expressed in most tissues of both virgin and lactating mice. However, differential accumulation of Stat5α and Stat5β mRNA has been reported for both muscle and mammary tissue. Stat5α is critically involved in a variety of physiological functions, including reproduction, lactation, immune function and somatic growth. The molecular weight of human Stat5α is 95 kDa.
Applications Reported
For research use only, not for diagnostic or therapeutic use. This polyclonal antibody has been reported for use in immunoprecipitation, immunoblotting (WB), and immunohistochemical staining.
Applications Tested
This polyclonal antibody has been tested by immunoblotting (WB) (5-10 μg/ml). A431 or tonsil cells can be used as positive controls. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
References
Frank DA. STAT signaling in the pathogenesis and treatment of cancer. Mol Med. 1999 Jul;5(7):432-56.
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