14-1959

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Contents: Affinity Purified anti-human CCR5 (CD195)
Catalog Number: 14-1959
Formulation: Phosphate buffer pH 7.2,
150 mM NaCl, 0.09% NaN₃
Storage Conditions: Store at 4°C.
Avoid repeated freeze/thaw cycles.
Clone: V14/2
Isotype: Mouse IgG1, κ
HLDA No.: N/A

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Cat. No.	Format	Excite (nm)	Emit (nm)	Reported Applications

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Description

The V14/2 monoclonal antibody is specific for the human CCR5, a member of the G protein-coupled receptor (GPCR) superfamily. CCR5 serves as the main coreceptor for the entry of R5 tropic strains of human immunodeficiency viruses (HIV) and is involved in the activation and migration of human leukocytes. Binding of RANTES/CCL5 to CCR5 induces protein phosphorylation mediated by protein kinase C (PKC) and GPCR kinase (GRK). These three antibodies are specific for different epitopes on the human CCR5 and recognize either activated phosphorylated epitopes or epitopes on the resting CCR5 molecules and are useful tools to study the expression and function of human CCR5.

Applications Reported

For research use only, not for diagnostic or therapeutic use. The V14/2 antibody has been reported for use in flow cytometric analysis, immunoblotting (WB), and ELISA.

Applications Tested

The V14/2 antibody has been tested by flow cytometric analysis of human peripheral blood leukocytes. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

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