Product Information

Contents: Affinity Purified anti-human CD41
Catalog Number: 14-0418
Sizes: 25 ug, 100 ug
Formulation: Phosphate buffer pH 7.2,
150 mM NaCl, 0.09% NaN₃
Storage Conditions: Store at 4°C.
Avoid repeated freeze/thaw cycles.
Clone: HIP2
Isotype: Mouse IgG3, κ
HLDA No.: IV P-39

Available Formats of This Product
Cat. No.	Format	Excite (nm)	Emit (nm)	Reported Applications
14-0418	Affinity Purified anti-human CD41b	N/A	N/A	FC
11-0418	FITC anti-human CD41b	488	518	FC

Questions? Please consult our answers to frequently asked questions at http://www.ebioscience.com/faq.

Description

The HIP2 monoclonal antibody reacts with the human CD41 molecule, a subunit of the integrin α_IIb also known as platelet GPIIb. CD41 non-covalently associates with integrin β₃ (GPIIIa, CD61) and is expressed by megakaryocytes and platelets. The CD41/CD61 complex is a receptor for fibronectin, fibrinogen, von Willebrand factor, vitronectin and thrombospondin and mediates platelets aggregation. HIP2 blocks platelet aggregation.

Applications Reported

For research use only, not for diagnostic or therapeutic use. The HIP2 antibody has been reported for use in flow cytometric analysis.

Applications Tested

The HIP2 antibody has been tested by flow cytometric analysis of human platelets. This can be used at less than or equal to 1 μg per 100 μl blood (or per 1 million cells in 100 μl total staining volume). It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

References

Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York.
Knapp, W., B. Dorken, et al. eds. (1989). Leucocyte Typing IV: White Cell Differentiation Antigens. Oxford University Press. New York.

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