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Human Cellular Antigens Chart

Contents: Affinity Purified anti-human CD41 Catalog Number: 14-0418 Formulation: Phosphate buffer pH 7.2, 150 mM NaCl, 0.09% NaN3 Storage Conditions: Store at 4°C. Avoid repeated freeze/thaw cycles. Clone: HIP2 Isotype: Mouse IgG3, κ HLDA No.: IV P-39 Prices for This Product* Cat. No. Size Price Qty Action 14-0418-80 25 ug $50 14-0418-82 100 ug $95 *International customers: Please contact your distributor for region specific pricing.

Available Formats of This Product
Cat. No.	Format	Excite (nm)	Emit (nm)	Reported Applications
11-0418	FITC anti-human CD41b	488	518	FC
14-0418	Affinity Purified anti-human CD41b	N/A	N/A	FC

Questions? Please consult our answers to frequently asked questions at http://www.ebioscience.com/faq.

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Description

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The HIP2 monoclonal antibody reacts with the human CD41 molecule, a subunit of the integrin α_IIb also known as platelet GPIIb. CD41 non-covalently associates with integrin β₃ (GPIIIa, CD61) and is expressed by megakaryocytes and platelets. The CD41/CD61 complex is a receptor for fibronectin, fibrinogen, von Willebrand factor, vitronectin and thrombospondin and mediates platelets aggregation. HIP2 blocks platelet aggregation.

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Applications Reported

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For research use only, not for diagnostic or therapeutic use. The HIP2 antibody has been reported for use in flow cytometric analysis.

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Applications Tested

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The HIP2 antibody has been tested by flow cytometric analysis of human platelets. This can be used at less than or equal to 1 μg per 100 μl blood (or per 1 million cells in 100 μl total staining volume). It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

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References

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Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York.
Knapp, W., B. Dorken, et al. eds. (1989). Leucocyte Typing IV: White Cell Differentiation Antigens. Oxford University Press. New York.

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Related Products

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Cat. 14-4742    Affinity Purified Mouse IgG3 Isotype Control