Contents: PE anti-human DR5 (CD262, Trail-R2, TrailR2)
Catalog Number: 12-9908
Formulation: Phosphate buffer pH 7.2,
150 mM NaCl, 0.09% NaN3, 0.2% BSA
Storage Conditions: Store at 4°C.
DO NOT FREEZE.
LIGHT-SENSITIVE MATERIAL.
Clone: DJR2-4 (a.k.a. 7-8)
Isotype: Mouse IgG1, κ
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Surface staining of human DR5 transfected cells with anti-human DR5 (DJR2-4) PE. Appropriate isotype controls were used (open histogram). Total viable cells were used for analysis.
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Description
The DJR2-4 monoclonal antibody reacts with human DR5, also known as TRAIL-R2, Apo2, TRICK2 and KILLER. DR5 binds to TRAIL, activates NF-κB, and induces TRAIL-mediated apoptosis. DR5 is expressed broadly by normal tissues as well as several tumor cells.
Applications Reported
For research use only, not for diagnostic or therapeutic use. The DJR2-4 (a.k.a. 7-8) antibody has been reported for use in flow cytometric analysis.
Applications Tested
The DJR2-4 (a.k.a. 7-8) antibody has been pre-titrated and tested by flow cytometric analysis of human peripheral blood leukocytes. This can be used at 20 μl (0.25 μg) per 100 μl blood (or per 1 million cells in 100 μl total staining volume).
References
Earel JK Jr, Vanoosten RL, Griffith TS. Histone deacetylase inhibitors modulate the sensitivity of tumor necrosis factor-related apoptosis-inducing ligand-resistant bladder tumor cells. Cancer Res. 2006 Jan 1;66(1):499-507. (FC,
PubMed)
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Human Cellular Antigens Chart