Product Information

Contents: Phycoerythrin (PE) anti-human CD155 (PVR)
Catalog Number: 12-1550
Sizes: 25 tests
Formulation: Phosphate buffered saline, pH 7.2, less than or equal to 0.09% NaN₃, BSA and/or gelatin for protein stabilization
Storage Conditions: Store at 4°C.
DO NOT FREEZE.
LIGHT-SENSITIVE MATERIAL.
Clone: 2H7CD155
Isotype: Mouse IgG1

Staining of U937 tumor cell line with 1 μg of PE Mouse IgG1, K Iso Cntrl (cat. 12-4714) (open histogram) or PE anti-human CD155 (2H7CD155) (colored histogram). Total viable cells were used for analysis.

Available Formats of This Product
Cat. No.	Format	Excite (nm)	Emit (nm)	Reported Applications
12-1550	Phycoerythrin (PE) anti-human CD155 (PVR)	488	575	FC

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Description

The monoclonal antibody 2H7CD155 recognizes CD155 also known as the poliovirus receptor. The CD155 protein is a member of the Ig superfamily in which 4 isoforms exist; only the α and δ forms are expressed on the membrane of monocytes and prostate cancer cells and neurectodermal and monocytic tumor cells lines. In addition CD155 is found during mid-gastrulation during embryonic development. CD155 is thought to play a role in adhesion by interaction with the ECM component vitronectin as well as a role in NK killingof tumor cells. CD226 and CD96 are ligands for CD155. Blocking of CD155 is under therapeutic investigation for prevention of variants of poliovirus.

Applications Reported

For research use only, not for diagnostic or therapeutic use. This 2H7CD155 antibody has been reported for use in flow cytometric analysis.

Applications Tested

This 2H7CD155 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells or human tumor cell line U937. This can be used at 20 μl (2 μg) per million cells in a 100 μl total staining volume.

References

Suzuki K, Nakamura K, Kato K, Hamada H, Tsukamoto T. Exploration of target molecules for prostate cancer gene therapy. Prostate. 2007 Aug 1;67(11):1163-73. (2H7CD155, FC, IP PubMed)

Related Products

Cat. 12-4714 Phycoerythrin (PE) Mouse IgG1, K Isotype Control