Product Information

Contents: Phycoerythrin (PE) anti-human CD41
Catalog Number: 12-0419
Sizes: 25 tests, 100 tests
Formulation: Phosphate buffer pH 7.2,
150 mM NaCl, 0.09% NaN₃, 0.2% BSA
Storage Conditions: Store at 4°C.
DO NOT FREEZE.
LIGHT-SENSITIVE MATERIAL.
Clone: HIP8
Isotype: Mouse IgG1, κ
HLDA No.: IV P38

CD41 expression on human platelets was determined using PE anti-human CD41 (HIP8).

Available Formats of This Product
Cat. No.	Format	Excite (nm)	Emit (nm)	Reported Applications
14-0419	Affinity Purified anti-human CD41a	N/A	N/A	FC IHC
11-0419	FITC anti-human CD41a	488	518	FC
12-0419	PE anti-human CD41a	488	575	FC

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Description

The HIP8 monoclonal antibody reacts with the human CD41 molecule, the integrin α_IIb also known as platelet GPIIb. CD41 non-covalently associates with integrin β₃ (GPIIIa, CD61) and is expressed by megakaryocytes and platelets. The CD41/CD61 complex is a receptor for fibronectin, fibrinogen, von Willebrand factor, vitronectin and thrombospondin and mediates platelets aggregation. HIP8 blocks platelet aggregation.

Applications Reported

For research use only, not for diagnostic or therapeutic use. The HIP8 antibody has been reported for use in flow cytometric analysis.

Applications Tested

The HIP8 antibody has been pre-titrated and tested by flow cytometric analysis of human peripheral blood leukocytes. This can be used at 20 μl (0.125 μg) per 100 μl blood (or per 1 million cells in 100 μl total staining volume).

References

Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York.
Knapp, W., B. Dorken, et al. eds. (1989). Leucocyte Typing IV: White Cell Differentiation Antigens. Oxford University Press. New York.

Related Products

Cat. 11-0418    FITC anti-human CD41b (clone HIP2)
Cat. 14-0418    Affinity Purified anti-human CD41b (clone HIP2)
Cat. 12-4714    Phycoerythrin (PE) Mouse IgG1, K Isotype Control