Contents: Phycoerythrin (PE) anti-human CD41
Catalog Number: 12-0419
Formulation: Phosphate buffer pH 7.2,
150 mM NaCl, 0.09% NaN3, 0.2% BSA
Storage Conditions: Store at 4°C.
DO NOT FREEZE.
LIGHT-SENSITIVE MATERIAL.
Clone: HIP8
Isotype: Mouse IgG1, κ
HLDA No.: IV P38
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CD41 expression on human platelets was determined using PE anti-human CD41 (HIP8).
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Questions? Please consult our answers to frequently asked questions at
http://www.ebioscience.com/faq.
Description
The HIP8 monoclonal antibody reacts with the human CD41 molecule, the integrin α
IIb also known as platelet GPIIb. CD41 non-covalently associates with integrin β
3 (GPIIIa, CD61) and is expressed by megakaryocytes and platelets. The CD41/CD61 complex is a receptor for fibronectin, fibrinogen, von Willebrand factor, vitronectin and thrombospondin and mediates platelets aggregation. HIP8 blocks platelet aggregation.
Applications Reported
For research use only, not for diagnostic or therapeutic use. The HIP8 antibody has been reported for use in flow cytometric analysis.
Applications Tested
The HIP8 antibody has been pre-titrated and tested by flow cytometric analysis of human peripheral blood leukocytes. This can be used at 20 μl (0.125 μg) per 100 μl blood (or per 1 million cells in 100 μl total staining volume).
References
Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York.
Knapp, W., B. Dorken, et al. eds. (1989). Leucocyte Typing IV: White Cell Differentiation Antigens. Oxford University Press. New York.
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Human Cellular Antigens Chart