Contents: Phycoerythrin (PE) anti-human CD11b (Integrin αM, Mac-1α)
Catalog Number: 12-0118
Formulation: Phosphate buffer pH 7.2,
150 mM NaCl, 0.09% NaN3, 0.2% BSA
Storage Conditions: Store at 4°C.
DO NOT FREEZE.
LIGHT-SENSITIVE MATERIAL.
Clone: ICRF44
Isotype: Mouse IgG1, κ
HLDA No.: IV M047
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Staining of normal human peripheral blood cells with staining buffer (autofluorescence) (open histogram) or PE ICRF44 (colored histogram). Cells in the lymphocyte (left) and monocyte (right) gates were used for analysis.
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Description
The ICRF44 monoclonal antibody reacts with human CD11b, a 165 kDa adhesion molecule. CD11b associated with integrin β
2 (CD18) is expressed on the surface of monocytes, granulocytes, activated lymphocytes and a subset of NK cells. CD11b is a receptor for intercellular adhesion molecule family members CD54, CD102 and CD50 as well as for iC3b. These adhesions are crucial in cell-cell and cell-matrix interactions.
Applications Reported
For research use only, not for diagnostic or therapeutic use. The ICRF44 antibody has been reported for use in flow cytometric analysis.
Applications Tested
The ICRF44 antibody has been pre-titrated and tested by flow cytometric analysis of human peripheral blood leukocytes. This can be used at 20 μl (0.5 μg) per 100 μl blood (or per 1 million cells in 100 μl total staining volume).
References
Knapp, W., B. Dorken, et al. eds. (1989). Leucocyte Typing IV: White Cell Differentiation Antigens. Oxford University Press. New York.
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Human Cellular Antigens Chart