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Contents: Fluorescein isothiocyanate (FITC) anti-human CD154 (CD40 Ligand, CD40L) Catalog Number: 11-1549 Formulation: Phosphate buffer pH 7.2, 150 mM NaCl, 0.09% NaN3, 0.2% BSA Storage Conditions: Store at 4°C. DO NOT FREEZE. LIGHT-SENSITIVE MATERIAL. Clone: B-B29 Isotype: Mouse IgG2a HLDA No.: N/A

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Description

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The B-B29 monoclonal antibody reacts with human CD154, a 39 kDa transmembrane glycoprotein also known as gp39 and CD40 ligand (CD40L). CD154 is a member of the TNF superfamily and is expressed transiently by activated T cells. Through its binding to CD40 on antigen presenting cells including B cells, monocytes/macrophages and dendritic cells, CD154 serves a crucial function in T-APC cognate interaction. CD154 interaction with CD40 transduces signals for T-dependent B-cell activation and induces B cell cycle entry.

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Applications Reported

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For research use only, not for diagnostic or therapeutic use. B-B29 has been reported for use in flow cytometric analysis.

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Applications Tested

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The B-B29 antibody has been pre-titrated and tested by flow cytometric analysis of human peripheral blood leukocytes. This can be used at 10 μl per 100 μl blood (or per 1 million cells in 100 μl total staining volume).

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References

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Kishimoto, T., A.E.G., von dem Borne, et al. eds. (1998). Leucocyte Typing VI: White Cell Differentiation Antigens. Garland Publishing Inc. London.

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