Product Information

Contents: Fluorescein isothiocyanate (FITC) anti-human CD41a
Catalog Number: 11-0419
Sizes: 25 tests, 100 tests
Formulation: Phosphate buffer pH 7.2,
150 mM NaCl, 0.09% NaN₃, 0.2% BSA
Storage Conditions: Store at 4°C.
DO NOT FREEZE.
LIGHT-SENSITIVE MATERIAL.
Clone: HIP8
Isotype: Mouse IgG1, κ
HLDA No.: IV P38

Available Formats of This Product
Cat. No.	Format	Excite (nm)	Emit (nm)	Reported Applications
11-0419	FITC anti-human CD41a	488	518	FC
12-0419	PE anti-human CD41a	488	575	FC
14-0419	Affinity Purified anti-human CD41a	N/A	N/A	FC IHC

Questions? Please consult our answers to frequently asked questions at http://www.ebioscience.com/faq.

Description

The HIP8 monoclonal antibody reacts with the human CD41 molecule, the integrin α_IIb also known as platelet GPIIb. CD41 non-covalently associates with integrin β₃ (GPIIIa, CD61) and is expressed by megakaryocytes and platelets. The CD41/CD61 complex is a receptor for fibronectin, fibrinogen, von Willebrand factor, vitronectin and thrombospondin and mediates platelets aggregation. HIP8 blocks platelet aggregation.

Applications Reported

For research use only, not for diagnostic or therapeutic use. The HIP8 antibody has been reported for use in flow cytometric analysis.

Applications Tested

The HIP8 antibody has been pre-titrated and tested by flow cytometric analysis of human peripheral blood leukocytes. This can be used at 20 μl (0.25 μg) per 100 μl blood (or per 1 million cells in 100 μl total staining volume).

References

Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York.
Knapp, W., B. Dorken, et al. eds. (1989). Leucocyte Typing IV: White Cell Differentiation Antigens. Oxford University Press. New York.

Related Products

Cat. 11-0418    FITC anti-human CD41b (clone HIP2)
Cat. 14-0418    Affinity Purified anti-human CD41b (clone HIP2)
Cat. 11-4714    Fluorescein isothiocyanate (FITC) Mouse IgG1, K Isotype Control