Product Information

Contents: Fluorescein isothiocyanate (FITC) anti-human CD41
Catalog Number: 11-0418
Sizes: 25 tests
Formulation: Phosphate buffer pH 7.2,
500 mM NaCl, 0.09% NaN₃, 0.2% BSA
Storage Conditions: Store at 4°C.
DO NOT FREEZE.
LIGHT-SENSITIVE MATERIAL.
Clone: HIP2
Isotype: Mouse IgG3, κ
HLDA No.: IV P-39

Available Formats of This Product
Cat. No.	Format	Excite (nm)	Emit (nm)	Reported Applications
14-0418	Affinity Purified anti-human CD41b	N/A	N/A	FC
11-0418	FITC anti-human CD41b	488	518	FC
Flow Cytometry Product Notes: Test Sizes: To accommodate multicolor flow cytometry, eBioscience is in the process of reducing test size volumes from 20 µl to 5 µl. Please check your antibody vial for the recommended test size. Fluorochrome Replacements: eBioscience is in the process of replacing all Pacific Blue® and APC-Alexa Fluor® 750 conjugated products with eFluor™ 450 and APC-eFluor™ 780 conjugated products, respectively.

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Description

The HIP2 monoclonal antibody reacts with the human CD41 molecule, a subunit of the integrin α_IIb also known as platelet GPIIb. CD41 non-covalently associates with integrin β₃ (GPIIIa, CD61) and is expressed by megakaryocytes and platelets. The CD41/CD61 complex is a receptor for fibronectin, fibrinogen, von Willebrand factor, vitronectin and thrombospondin and mediates platelets aggregation. HIP2 blocks platelet aggregation.

Applications Reported

For research use only, not for diagnostic or therapeutic use. The HIP2 antibody has been reported for use in flow cytometric analysis.

Applications Tested

The HIP2 antibody has been pre-titrated and tested by flow cytometric analysis of human peripheral blood leukocytes. This can be used at 20 μl (2 μg) per 100 μl blood (or per 1 million cells in 100 μl total staining volume).

References

Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York.
Knapp, W., B. Dorken, et al. eds. (1989). Leucocyte Typing IV: White Cell Differentiation Antigens. Oxford University Press. New York.

Related Products

Cat. 11-0419  FITC anti-human CD41a (clone HIP8)
Cat. 12-0419  PE anti-human CD41a (clone HIP8)
Cat. 14-0419  Affinity Purified anti-human CD41a (clone HIP8)
Cat. 11-4742  FITC Mouse IgG3 Isotype Control