Contents: Fluorescein isothiocyanate (FITC) anti-human CD1a
Catalog Number: 11-0019
Formulation: Phosphate buffered saline, pH 7.2, less than or equal to 0.09% NaN3, BSA and/or gelatin for protein stabilization
Storage Conditions: Store at 4°C.
DO NOT FREEZE.
LIGHT-SENSITIVE MATERIAL.
Clone: HI149
Isotype: Mouse IgG1, κ
HLDA No.: V 5T CD01.01
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Staining of MOLT-4 cells with FITC Mouse IgG1, K Iso Cntrl (cat. 11-4714) (open histogram) or FITC anti-human CD1a (HI149) (colored histogram). Total viable cells were used for analysis.
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Description
The HI149 monoclonal antibody reacts with human CD1a, a 49 kDa protein expressed by cortical thymocytes and dendritic cells including Langerhans cells. The CD1 family of proteins share some structural and functional characteristics with the MHC class I molecules; however, members of the CD1 family are not polymorphic. Similar to MHC class I, CD1a associates with the β2-microglobulin and is thought to play a role in antigen presentation.
Applications Reported
For research use only, not for diagnostic or therapeutic use. The HI149 antibody has been reported for use in flow cytometric analysis.
Applications Tested
This HI149 antibody has been pre-titrated and tested by flow cytometric analysis of MOLT-4 cells. This can be used at 20 μl (0.5 μg) per million cells in a 100 μl total staining volume.
References
Knapp, W., B. Dorken, et al. eds. (1989). Leucocyte Typing IV: White Cell Differentiation Antigens. Oxford University Press. New York.
Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York.
Related Products
Cat.
11-4714 Fluorescein isothiocyanate (FITC) Mouse IgG1, K Isotype Control
Human Cellular Antigens Chart