Anti-Cytochrome C Purified

Description: This 7H8 monoclonal antibody recognizes human, mouse, and rat cytochrome c, an 11-kDa heme-binding protein found in plants, animals, and other organisms. Cytochrome c is associated with the inner membrane of the mitochondrion. This molecule plays a role in electron transfer during cellular respiration. Moreover, in response to pro-apoptotic stimuli and subsequent calcium level elevation, cytochrome c is released from mitochondria, leading to caspase activation.

References: Jemmerson R, Johnson JG, Burrell E, Taylor PS, Jenkins MK. A monoclonal antibody specific for a cytochrome c T cell stimulatory peptide inhibits T cell responses and affects the way the peptide associates with antigen-presenting cells. Eur J Immunol. 1991 Jan;21(1):143-51.

Goshorn SC, Retzel E, Jemmerson R.Common structural features among monoclonal antibodies binding the same antigenic region of cytochrome c. J Biol Chem. 1991 Feb 5;266(4):2134-42.