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Th17 Cells

CD4+ T helper cells are critical mediators of the cellular immune response. For many years, it was thought that CD4+ T helper cells existed as a dichotomy of lineages identified as Th1 and Th2 based on their expression pattern of effector cytokines. This paradigm was challenged with the demonstration that IL-17 (also known as IL-17A) was produced and secreted as a homodimer or heterodimer (with IL-17F) by a unique subset of T helper cells with the subsequent identification of ROR gamma (t) as the transcription factor responsible for specifying the lineage differentiation of Th17 cells. Th17 cell development is also driven and regulated by the expression of transcription factors STAT3, AHR, BATF, IRF4, c-Maf, IKB zeta and ROR alpha. Th17 cells play a role in host defense against extracellular pathogens and there is significant evidence that aberrant regulation of Th17 cells plays a role in the pathogenesis of multiple inflammatory and autoimmune disorders.

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9 Item(s)

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Name Clone Application Cat. No. Reg.  

Anti-Human CD3 APC

SK7 FC 17-0036 RUO

Anti-Human CD3 APC-eFluor® 780

SK7 FC 47-0036 RUO

Anti-Human CD3 eFluor® 450

SK7 FC 48-0036 RUO

Anti-Human CD3 Functional Grade Purified

SK7 FC, FA 16-0036 RUO

Anti-Human CD3 PE

SK7 FC 12-0036 RUO

Anti-Human CD3 PE-Cyanine7

SK7 FC 25-0036 RUO

Anti-Human CD3 PE-Cyanine5.5

SK7 FC 35-0036 RUO

Anti-Human CD3 PerCP-Cyanine5.5

SK7 FC 45-0036 RUO

Anti-Human CD3 PerCP-eFluor® 710

SK7 FC 46-0036 RUO

9 Item(s)

Set Descending Direction
25 | 50

* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents