**Starting now: ebioscience.com products are on thermofisher.com. Ebioscience.com to retire in April. Get details >


Th17 Cells

CD4+ T helper cells are critical mediators of the cellular immune response. For many years, it was thought that CD4+ T helper cells existed as a dichotomy of lineages identified as Th1 and Th2 based on their expression pattern of effector cytokines. This paradigm was challenged with the demonstration that IL-17 (also known as IL-17A) was produced and secreted as a homodimer or heterodimer (with IL-17F) by a unique subset of T helper cells with the subsequent identification of ROR gamma (t) as the transcription factor responsible for specifying the lineage differentiation of Th17 cells. Th17 cell development is also driven and regulated by the expression of transcription factors STAT3, AHR, BATF, IRF4, c-Maf, IKB zeta and ROR alpha. Th17 cells play a role in host defense against extracellular pathogens and there is significant evidence that aberrant regulation of Th17 cells plays a role in the pathogenesis of multiple inflammatory and autoimmune disorders.

Suggest a new product or place a custom order.

5 Item(s)

Set Descending Direction
25 | 50
Name Clone Application Cat. No. Reg.  

Anti-Canine CD4 APC

YKIX302.9 FC 17-5040 RUO

Anti-Canine CD4 FITC

YKIX302.9 FC 11-5040 RUO

Anti-Canine CD4 PE-Cyanine7

YKIX302.9 FC 25-5040 RUO

ProcartaPlex Canine Cytokine/Chemokine/Growth Factor Panel 1 (11 plex)

Multiplex EPX11A-50511 RUO

ProcartaPlex Canine IL-6 Simplex

Multiplex EPX01A-50505 RUO

5 Item(s)

Set Descending Direction
25 | 50

* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents